Megakaryocytes contain extranuclear histones and may be a source of platelet-associated histones during sepsis
نویسندگان
چکیده
منابع مشابه
Histones
JAUNDICE DURING PREGNANCY. By Urs Peter Haemmerli. New York, Springer-Verlag, Inc., 1967. 111 pp. $3.80, paperbound. Jaundice During Pregnancy is an excellent monograph which should be read by all internists, obstetricians, and pediatricians, and which should be available in all medical libraries for ready reference. The author concisely summarizes the known minor alterations of the liver and i...
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Despite advances in management over the last several decades, sepsis and acute respiratory distress syndrome (ARDS) still remain major clinical challenges and the leading causes of death for patients in intensive care units (ICUs) due to insufficient understanding of the pathophysiological mechanisms of these diseases. However, recent studies have shown that histones, also known as chromatin-ba...
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Nuclear DNA is tightly packaged into chromatin, which profoundly influences DNA replication, transcription, repair, and recombination. The extensive interactions between the basic histone proteins and acidic DNA make the nucleosomal unit of chromatin a highly stable entity. For the cellular machinery to access the DNA, the chromatin must be unwound and the DNA cleared of histone proteins. Conve...
متن کاملExtranuclear detection of histones and nucleosomes in activated human lymphoblasts as an early event in apoptosis.
OBJECTIVE To evaluate the presence of histones and nucleosomes in cell lysates of freshly isolated peripheral blood mononuclear cells (PBMC), fully activated lymphoblasts, or lymphoblasts after induction of apoptosis. METHODS Each histone class (H1, H2A, H2B, H3, and H4) was detected by western blot analysis with specific antibodies. Annexin V/propidium iodide (PI) staining was performed for ...
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Trout testis cells were incubated with 13H]arginine and lysine and inorganic [32P]phosphate. Histones were extracted with acid and the major fractions (I, IIbl, IIb2, III monomer, and IV) were resolved by chromatography on BioGel P-10. The profile of 32P incorporation was time dependent. When the phosphorylated histones in each of the major fractions were resolved from unphosphorylated species ...
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ژورنال
عنوان ژورنال: Scientific Reports
سال: 2020
ISSN: 2045-2322
DOI: 10.1038/s41598-020-61309-3